Optimizing efavirenz treatment: CYP2B6 genotyping or therapeutic drug monitoring?
نویسندگان
چکیده
منابع مشابه
Successful efavirenz dose reduction guided by therapeutic drug monitoring.
BACKGROUND There are potential benefits to individualizing dosage in patients treated with efavirenz (EFV). We tested a simplified algorithm based on a Bayesian pharmacokinetic approach for guiding dose reduction in patients with EFV concentrations above the 75th percentile (P75) with documented virological efficacy. METHODS We designed a prospective, open-label, multicentre study. All consen...
متن کاملEfavirenz and CYP2B6 polymorphism: implications for drug toxicity and resistance.
The brief history of pharmacogenetics has been marked by a high level of public as well as professional interest, reflecting in many respects the great promise offered by genomic approaches to biology, clinical medicine, and pharmacology over the past ∼15 years. This early interest in person-alized medicine was fueled by reviews [1, 2] in which it was predicted that drug prescribing could be un...
متن کاملCost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice.
AIMS To assess the cost-effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. METHODS We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model to project quality-adjusted life expectancy and lifetime costs (2014 US dollars) for efavirenz-based HIV therapy with or without CYP2B6 genotyping. We assumed that with gen...
متن کاملTherapeutic drug monitoring in epilepsy treatment
Drug monitoring as a means to adapt the dosage of antiepileptic drugs to achieve a particular concentration in blood is well documented. However, there are few studies showing the extent to which drug monitoring contributes toward greater effectiveness in epilepsy treatment as measured by better seizure control. The findings of SBU Alert show that there is currently poor* evidence to demonstrat...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2008
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-007-0440-z